Iminosugar-producing Thai medicinal plants.
نویسندگان
چکیده
Alpha-1-C-hydroxymethylfagomine (7), 3-O-beta-D-glucopyranosyl-DMDP (12), and 2,5-dideoxy-2,5-imino-D-glucitol (13) were isolated from the Thai traditional crude drug "Non tai yak" (Stemona tuberosa), which also contains a high concentration level of alpha-homonojirimycin (0.1% dry weight). "Thopthaep" (Connarus ferrugineus) and "Cha em thai" (Albizia myriophylla) contained 1-deoxymannojirimycin (DMJ) (10) at levels of 0.083% (dry weight) and 0.17% (dry weight), respectively. 2-O-alpha-D-Galactopyranosyl-DMJ (20), 3-O-beta-D-glucopyranosyl-DMJ (21), 1,4-dideoxymannojirimycin (17), 1,4-dideoxyallonojirimycin (18), and 1,4-dideoxyaltronojirimycin (19) from C. ferrugineus and 2-O-beta-D-glucopyranosyl-DMJ (22) and 4-O-beta-D-glucopyranosyl-DMJ (23) from A. myriophylla were isolated as new compounds.
منابع مشابه
Chasing the Key Enzymes of Secondary Metabolite— Biosynthesis from Thai Medicinal Plants
Novel enzymes involved in the biosynthesis of plant secondary metabolites have been discovered in our laboratory from both differentiated plants and in vitro cultures of Thai medicinal plants. The discovered enzymes included (1) geranylgeraniol-18-hydroxylase from Croton sublyratus containing plaunotol, an anti-peptic ulcer diterpenoid, (2) dopamine-secologanin condensing enzymes from Alangium ...
متن کاملEthnomedicinal plants used by traditional healers in Phatthalung Province, Peninsular Thailand
BACKGROUND In rural communities of Thailand, traditional healers still play an important role in local health care systems even though modern medicine is easily accessible. Meanwhile, natural forests in Thailand which are important sources of materia medica are being greatly destroyed. This has led to an erosion of traditional Thai medicine. Furthermore, the concept of medicinal plant selection...
متن کاملAntibacterial Activity of Ethanol Extract from Some Thai Medicinal Plants against Campylobacter Jejuni
In this study, the forty Thai medicinal plants were used to screen the antibacterial activity against Campylobacter jejuni. Crude 95% ethanolic extracts of each plant were prepared. Antibacterial activity was investigated by the disc diffusion assay, and MICs and MBCs were determined by broth microdilution. The results of antibacterial screening showed that five plants have activity against C.j...
متن کاملSynthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors.
Novel bicyclic iminosugar derivatives fused thiazolidin-4-one were conveniently synthesized by double Pummerer rearrangements, and their HIV reverse transcriptase (RT) inhibitory activities were preliminary examined. The notable anti-HIV-RT activity demonstrated that such bicyclic azasugars hold potential as a new kind of HIV-RT inhibitors.
متن کاملImmunomodulatory Effects of Thai Medicinal Plants on the Mitogen Stimulated Proliferation of Human Peripheral Blood Mononuclear Cells in Vitro
The immunomodulatory effects of Thai medicinal plants, including Murdannia loriformis, Cymbopogon citratus, Momornica charantia, Centella asiatica, Allium sativum, Carthamus tinctorius, Eclipta alba, Cyperus rotundus, lotus pollen (Dee-Buo), and plant embryos in seeds of the lotus (Ke-Sorn-Buo), on the mitogen stimulated proliferation of human peripheral blood mononuclear cells (PBMCs) were inv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of natural products
دوره 68 8 شماره
صفحات -
تاریخ انتشار 2005